The smash on the A40 in Harrow, North London, which has left a man and a woman dead, came after an aggravated burglary was reported to police at around 8.40pm.
A witness said the car "crashed through some railings and into the coach" before bursting into flames.
In a statement, the Met Police said: "As part of this response, a vehicle pursuit was initiated. The police helicopter was also called to assist.
"At approximately 9pm the vehicle being pursued moved onto the wrong side of the carriageway on the A40. The police vehicles did not follow.
"The vehicle was then in collision with a coach. There were three occupants in the vehicle.
"Two people – one male and one female – were pronounced dead at the scene; a second male has been taken to hospital for treatment."
Someone is lying dead in the road outside my flat
Police said there are no reports of any other serious injuries following the horrifying collision.
A local resident name Lucy said: "Someone is lying dead in the road outside my flat…"
Describing the crash, she tweeted: "Car crashed through some railings and into a coach after a police chase, car burst into flames, every emergency vehicle in London turned up, pulled dead driver out, covered body with tent which is now just lying unattended…"
Road closures remain in place following the smash.
Emergency vehicles including ambulances and fire engines attended the scene.
More to follow…
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