EastEnders' Lalia Morse and Christine McGuiness, wife of comedian Paddy, are among the stars who have signed up for The Real Full Monty.
Former Strictly Come Dancing stars James and Ola Jordan, Blue singer Duncan James will also join the celebrities taking the plunge and stripping off for Strictly The Real Full Monty.
Also baring all to raise awareness for cancer checks will be Olympian Colin Jackson, Loose Women panellist Brenda Edwards, TV presenter Martin Roberts and Love Island stars Teddy Soares and Demi Jones.
The striptease show will again be presented by choreographer and mentor Ashley Banjo, who will support and lead the celebrities, who have all been touched by cancer.
Jones, who rose to fame on the 2020 series of ITV2 dating show Love Island, previously revealed she has thyroid cancer and has had a tumour removed.
Reality star Demi has been open about her cancer battle and recalled how she cried when she first found out about her diagnosis.
"I remember leaving the hospital room and I got into my car and I just sat down. I was crying so much cause it's just actually hit me," she explained.
"Even though it's a treatable cancer, I still feel like, what could this do? Is this gonna kill me? Am I gonna be really poorly?"
Banjo said of the line-up: “I’m so excited to be working with a new brilliant, bold and brave line-up of celebrities for Strictly The Real Full Monty.
“It’s going to be our biggest musical dance extravaganza yet and we are determined to get the message out there that early cancer checks in intimate areas save lives. So don’t forget to check your bits and baubles this Christmas!”
ITV factual commissioner Kate Teckman added: “This year we’re bringing our message with a bang by adding a huge dose of sequins, sparkles, sambas and salsas to the strip.
“There will also be star guest performances and stunning solos so hold on to your mirror balls – this is strictly the most ambitious Full Monty yet!”
Other stars who have previously stripped off for the show include Coleen Nolan, Victoria Derbyshire and John Partridge.
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