Children are 'silent super spreaders' of Covid-19, scientists claim

Are children silent super spreaders of Covid-19? Scientists find youngsters with mild symptoms have bigger viral loads than hospitalised adults

  • Children with Covid-19 had more viral loads in their nose than adults
  • This may confer an increased ability to transmit the disease to others
  • But children often show no tell-tale symptoms, meaning they don’t get tested
  • The findings are in contrast to other studies looking at the role of children in the pandemic, and scientists said the claims were ‘largely unfounded’ 

Children may be silent super spreaders of Covid-19 because they have high viral loads, a study has claimed.

Youngsters were shown to carry large amounts of the coronavirus in their nose, which scientists say may suggest they have an increased ability to transmit the virus to others. 

Infected children with mild symptoms even had bigger viral loads than adults who had been hospitalised by the life-threatening disease. 

Having a high viral load — the number of particles of the virus someone is infected with — may make people more contagious, evidence suggests. It can also give the bug a ‘jump start’.

Yet children carrying the virus often show show none of the tell-tale signs, meaning they don’t get tested and unknowingly pose a risk to family members, including their vulnerable grandparents.

The findings came from comparing nose, throat and blood samples of 49 Covid-19 cases under the age of 22 against ones from adults hospitalised by the disease. 

But the results are in direct contrast to other studies which have shown children are far less contagious than adults, although not less susceptible to catching the illness in the first place.

Experts said the findings were ‘unfounded’ and ‘misleading’ because the children still had symptoms and would not be walking around schools in real-life. 

The role of children in the spread of the coronavirus is highly contested because it has huge implications for the re-opening of schools, which has been the subject of fierce debate in Britain.  

Researchers at Massachusetts General Hospital behind the study said: ‘If schools were to re-open fully without necessary precautions, it is likely children will play a larger role in this pandemic.’   

The graph shows how viral loads (measure from 0 to 10) were higher in children (plotted in red), particularly in the first two days, than hospitalised adults (plotted in black)

Lead author Dr Lael Yonker said: ‘I was surprised by the high levels of virus we found in children of all ages, especially in the first two days of infection. I was not expecting the viral load to be so high.’

In the study, published in the Journal of Pediatrics today, 192 at-risk youngsters up to the age of 22 were tested for Covid-19. More than a quarter (49) tested positive for SARS-CoV-2. But only half had any of the virus’ classic symptoms.  

Yet infected youngsters were found to have to have a significantly higher level of virus in their airways than 162 adults who had been hospitalised with the virus. 

Viral loads in children reached 6.2 out of ten within the first 48 hours of showing any symptoms, data showed.  

In comparison, the figure for adults was just five on average. Dr Yonker said: ‘You think of a hospital, and of all of the precautions taken to treat severely ill adults.

‘But the viral loads of these hospitalised patients are significantly lower than a “healthy child” who is walking around with a high SARS-CoV-2 viral load.’ 

The ability to spread the virus rises in line with the amount of virus the individual is carrying in their nose and airways, the researchers said, but they did not prove this in their study.

The viral loads of the children decreased over time 

ARE CHILDREN IMMUNE TO COVID-19? 

Children are unlikely to fall seriously ill with Covid-19 and the risk of them dying from the disease is very low, dozens of studies have shown.

Scientists warn children are not immune, however. Anyone can get infected with the virus — technically called SARS-CoV-2.

But eight months since the pandemic began in China, doctors around the world are still baffled as to why youngsters appear resistant to the disease.

Reasons for their resilience to the disease are still unclear, despite a wave of trials devoted to unraveling the truth on the contentious topic.

Evidence shows the coronavirus preys on existing ill health and is most dangerous for the elderly. In comparison, the flu poses a big threat to children.

Barely any children have died of Covid-19. Only six under-14s have succumbed to the illness in England and Wales, according to official data.

Cambridge University’s Sir David Spiegelhalter said their risk was ‘unbelievably low’, adding: ‘I don’t think any [group] has been safer in the history of humanity.’

Statisticians analysing the outbreak in the UK even say youngsters are more likely to be hit by lightning than be killed by the virus.

Cambridge academics say the death rate for under-14s is around 0.00068 per cent — the equivalent of seven deaths for every million cases.

London School of Hygiene and Tropical Medicine researchers found in June that children often escape the disease without any symptoms.

Only 21 per cent of infected 10 to 19-year-olds had symptoms. By contrast, the rate of symptoms among over-70s was three times higher.

Getting fewer symptoms and milder illness may make children less likely to spread it, other researchers have claimed.

But two major studies last week, from China and Germany, concluded that children are capable of transmitting the virus.

Some academics believe youngsters are better protected against Covid-19 because they are used to catching other less harmful coronaviruses.

This may then teach their immune system to recognise SARS-CoV-2, allowing them to fight off the infection without getting seriously ill.

Other experts say their body may be faster to react or their bodies better able to cope with viral infections because they are younger.

They pointed out children with Covid-19 are not as likely to become seriously ill as adults, which echoes previous studies finding severe disease to be unlikely in young people.

And even when children exhibit symptoms typical of Covid-19, they often overlap with common childhood illnesses, including influenza and the common cold. 

The researchers warn that, because children are so often asymptomatic — meaning they show no symptoms, they could be spread the infection at school and bring it home without knowing. 

This is a particular concern for families in certain socio-economic groups and multi-generational households where children live with both their parents and grandparents, the researchers said. 

In the study, half of children with Covid-19 came from low-income communities — compared to two per cent from high-income.

Along with the viral load, researchers examined how susceptible children were to catching the virus based on expression of their receptors.

SARS-CoV-2 is thought to enter cells by using ACE-2 receptors on cell surfaces, which acts as a ‘doorway’.  

Children under ten years old were found to have lower numbers of the receptor in their airways, compared to older peers and adults.

But this did not correlate with a decreased viral load, which the researchers said suggests children can be more contagious, regardless of their susceptibility to developing Covid-19 in the first place.

Professor Alessio Fasano, who was involved in the study, said: ‘Kids are not immune from this infection, and their symptoms don’t correlate with exposure and infection.

‘During this Covid-19 pandemic, we have mainly screened symptomatic subjects, so we have reached the erroneous conclusion the vast majority of people infected are adults.

‘However, our results show kids are not protected against this virus. We should not discount children as potential spreaders for this virus.’

Professor Fasano fears a hurried return to school without proper planning could result in an uptick in cases of Covid-19 infections. 

The study recommended routine screening of children for infection and control measures in the classroom, like mask wearing. 

But scientists who were not involved with the research said to suggest children are super spreading people is ‘unfounded’.

Dr Andrew Preston, a reader in microbial pathogenesis at the University of Bath, said: ‘In my opinion many of the statements in this paper are largely unfounded. 

‘[The conclusions are] very misleading because the study was limited to symptomatic children. It is recognised that symptomatic individuals likely pose a greater risk of transmission than asymptomatic individuals. 

‘The discussion appears to suggest children in general will be walking around with high viral loads, when in fact this study was limited to small numbers of children with symptoms. 

‘Those displaying symptoms would be isolating, not walking around in schools.’

Dr Simon Clarke, an associate professor in cellular microbiology at the University of Reading, said: ‘In my opinion the headline of the press release is very misleading, because the study does not actually demonstrate that children spread the virus.”

‘It does not demonstrate, in any way, that children actually spread of the virus to adults or other children.”

Adilia Warris, a professor of paediatric infectious diseases at the University of Exeter, said: ‘The study was not designed to assess risk of transmission. Although a high viral load contributes to the level of contagiousness, it is not the only factor playing a role.’

The study also looked at the immune systems of 18 children who developed MIS-C – a recently named condition linked to Covid-19 that scientists have been racing to understand it during the pandemic.

It develops several weeks after infection with Covid-19 and the symptoms are similar, but slightly different, to Kawasaki disease. 

The disease can manifest itself as a rash, fever and abdominal pain. But it can be life-threatening, leading to severe cardiac problems, shock and acute heart failure. 

The researchers found that children with severe MISC-C were suffering from ‘hyperactive’ immune responses to Covid-19, when the body goes into overdrive and attacks healthy tissue. 

It led them to believe that this overreaction by the immune system as it fights the viral disease is behind the mystery illness. 

Professor Fasano said: ‘This is a severe complication as a result of the immune response to Covid-19 infection, and the number of these patients is growing.

‘And, as in adults with these very serious systemic complications, the heart seems to be the favourite organ targeted by post-Covid-19 immune response.’  

WHAT DOES THE RESEARCH SAY ABOUT CHILDREN’S ABILITY TO SPREAD COVID-19? 

Older pupils spread the virus ‘like adults do’ 

Secondary school pupils are as likely to transmit coronavirus as adults, according to a Public Health England study revealed last week.

Education Secretary Gavin Williamson has said PHE findings due to be published later this year showed there was little risk from the Government’s plans to reopen schools in England in September.

The education secretary said the ‘latest research, which is expected to be published later this year — one of the largest studies on the coronavirus in schools in the world’, would make it ‘clear there is little evidence that the virus is transmitted at school’. 

However The Times reported that while there was little risk from primary schools, researchers who had worked on the study were unhappy with the way their findings, which have not yet been fully analysed, had been used by ministers —who argue that it is safe for all children to return to class at the start of next term.

While preliminary results of the study —which separated children into those older than 10 and those younger —indicate that primary schools are not a significant danger, with just six positive test results out of 9,000 tested so far, it is believed that a difference was found in the older group.

A source claimed the study suggested that as pupils grow older ‘their bodies start to act like small adults’ as they spread the virus more effectively.

A PHE spokesperson said: ‘PHE analysis of recorded cases and outbreaks in educational settings in England is currently undergoing pre-publication verification and review, and will be published in due course.

‘It appears to show that SARS-CoV-2 infections and outbreaks were uncommon in educational settings during the first month after the easing of national lockdown in England.’

‘Additionally, a nationwide surveillance programme examining antibody prevalence in schoolchildren (sKIDs), is being analysed and should be published in the coming weeks.

‘These publications combined will give the most complete picture of the landscape of Covid-19 in educational settings that we have seen to date.’

Schools are ‘minor players’ in the overall transmission of coronavirus

Professor Russell Viner, president of the Royal College of Paediatrics and Child Health, said schools are ‘minor players’ in the transmission of coronavirus, and ‘we owe it to our children’ to re-open schools.

He said parents should be ‘reassured’ by growing evidence from countries including Germany, Singapore and the Netherlands, which shows ‘little significant transmission in schools’.

Professor Viner, who also sits on the Government’s Scientific Advisory Group, said returning next month was likely to ‘add little’ to the reproduction rate of infection. 

He told BBC Radio 4’s Today programme on August 10 that reopening schools is one of the ‘least risky things we can do’.  

He said: ‘There’s always dangers with evidence but I think the evidence from around the world is starting to become convincing that for younger children, particularly primary school children, that they appear to be less likely to catch this virus, and they don’t play a big role in transmitting it.’  

Professor Viner highlighted the ‘higher rates of some concerning conditions’, observed in children’s absence from school, including obesity.

Schoolchildren ‘do not spread the virus as much as staff do’

Research in Australia – one of the only countries to keep its schools open during the pandemic – found that children do not transit the coronavirus to other people as much as staff do, suggesting adults are more capable of spreading the disease.

The team led by Professor Kristine Macartney identified all staff and children who attended a school or nursery in the Australian state of New South Wales while they had Covid-19.

Overall, 12 children and 15 adults were found to have attended schools or nurseries while infectious between 25 January to 10 April, when term ended.

All adults or the parents of children were interviewed at diagnosis to track who the cases had been in contact with during the time that they were infectious.

The team showed that, of the 633 close contacts who were tested following symptoms, 18 were found to have Covid-19.

Further analysis of a subset of schools showed the transmission rate between staff (4.4 per cent) was much higher than between children (0.3 per cent), suggesting children do not spread the virus as much as adults.

The attack rate from child to staff was one per cent for child-to-staff, compared to 1.5 per cent the other way around, according to the findings published in the journal The Lancet Child and Adolescent Health on August 3.

The researchers, led by Professor Kristine Macartney also said the transmission rates may have been higher in areas where contact tracing systems and testing were not as rigorous.

An Australian study found the transmission rate between staff (4.4 per cent) was much higher than between children (0.3 per cent), suggesting children do not spread the virus as much as adults

Teenagers ‘spread the coronavirus as much as adults do’

A South Korean study found children under 10 transmitted less often to adults while those between the ages of 10 and 19 spread the virus as well as adults do.

The researchers at Korea Centers for Disease Control and Prevention looked at 5,706 infected people and studies their 59,073 contacts for around nine days to see who was later diagnosed.

They detected Covid-19 in 11.8 per cent of household contacts, and rates were higher for contacts of children than adults. 

Households with the older children had the highest rate of spread to other members—18.6 per cent— of any age group.

Only those in their 70s had an attack rate as high (18 per cent), followed by those in their 50s (17 per cent) and their 40s (11.8 per cent). 

Households with younger children had the least spread, just 5.3 per cent, according to the findings which will be published in the autumn edition of Emerging Infectious Diseases.   

Outside of the home, teenagers didn’t pose as much threat, with 0.9 per cent of their contacts testing positive compared with 4.8 per cent in the 70 to 79 age bracket. 

The authors wrote: ‘Young children may show higher attack rates when the school closure ends, contributing to community transmission of Covid-19.’

A study in South Korea found those aged 10-19 passed the coronavirus on to 18.6 per cent of their household contacts, and 0.9 per cent of their contact outside the home

Children without symptoms ‘may spread the disease more’

Independent SAGE ⁠— a group of experts set up with of providing ‘robust, independent advice’ to the UK Government during Covid-19 — has previously warned that children could spread coronavirus simply because they are not detected as a case. 

Children may be just as likely to catch the coronavirus as adults but don’t seem to be diagnosed often.

This is for two reasons ⁠— children to do not show the typical symptoms that adults to, if at all, and testing was only expanded to children in May. 

A report from Independent SAGE published in May, which discussed whether schools should re-open on June 1, said: ‘Studies have shown that between one per cent and five per cent of diagnosed Covid-19 cases are in children, but many children may be undiagnosed because up to a third of infected children never develop any symptoms (Ludvigsson, 2020).  

‘Current UK data suggest that they are as likely as adults to become infected and carry the virus but they may be less likely than adults to transmit the virus because, for instance, adults are contagious for longer than children.

‘However, the impact of placing many children in one place could lead schools to become ‘institutional amplifiers’ if asymptomatic children go unnoticed until an adult becomes symptomatic.’  

Children’s viral loads are up to 100 times higher than adults’, making them more infectious 

Children under five years old can transmit the novel coronavirus just as easily as older kids can, a study in July claimed.

Researchers from Ann & Robert H. Lurie Children’s Hospital of Chicago collected nasopharyngeal swabs from children at a paediatric tertiary medical center in Chicago.

They looked at 145 patients who developed to moderate illness within one week of experiencing symptoms, according to the findings published in JAMA Pediatric.

Three groups were compared: children younger than age five, children between ages five and 17 years and adults from ages 18 to 65.

The findings shows that although children kindergarten-age or younger only have mild illness, they had viral loads between 10-fold and 100-fold greater amount in their upper respiratory tract.

‘We found that children under five with Covid-19 have a higher viral load than older children and adults, which may suggest greater transmission, as we see with respiratory syncytial virus, also known as RSV,’ said lead author Dr Taylor Heald-Sargent, a paediatric infectious diseases specialist at Lurie Children’s.

‘Our study was not designed to prove that younger children spread Covid-19 as much as adults, but it is a possibility.’

This implies that young children can spread the virus just as easily as teenagers, despite only developing a mild illness

Children have a lower viral load than adults, therefore cannot spread the virus as much

Eminent statistician Sir David Spiegelhalter claimed in May that children carry just a fraction of the viral load compared to adults, which significantly reduces their ability to fall ill or infect others.

Professor Spiegelhalter condemned a German pre-published study that suggested children carry the same viral load of COVID-19 as adults.

Because youngsters get much more mild symptoms, the results raised fears children could become super-spreaders.

However the statistician said the data clearly had been misinterpreted because it actually showed children have just a quarter of the viral load of adults.

He told the BBC: ‘One of the big problems with this epidemic is that claims are being rushed out. Peer -review [when other scientists scrutinise research] has just disappeared from scientific analyses and yet they get a lot of media coverage.

‘It is widely claimed that children have got the same viral load as adults, from a German study.

‘If you look at that study it shows that is clearly not the case, children have about a quarter of the viral load according to the study. It’s a very poor statistical analysis.’

Eminent statistician Sir David Spiegelhalter claimed in May that children carry just a fraction of the viral load compared to adults, which significantly reduces their ability to infect others

Children under 15 ‘rarely transmit the virus’

Professor Mark Woolhouse, an epidemiologist from the University of Edinburgh, said that children of school age up to 15 are ‘minimally involved in the epidemiology of this virus’.

The professor, who sits on a sub-group of SAGE, told The Times on July 21 it is ‘extremely difficult’ to find any instances of children spreading the virus to adults in schools, with no certain cases.

He said: ‘There is increasing evidence that they rarely transmit.

‘For example, it is extremely difficult to find any instance anywhere in the world as a single example of a child transmitting to a teacher in school. There may have been one in Australia but it is incredibly rare.

‘There are certain environments where this virus transmits very well and children are not present in these environments.’

He suggests closing schools was ‘never essential’ and said it was unlikely that governments would repeat the drastic step.

Evidence now suggests children are ‘minimally involved’ in the spread of Covid-19, which politicians should bear in mind in the future, he added.

Children are unlikely to spread the disease because they don’t catch it in the first place

One study by University College London claimed children are unlikely to be involved with transmission of the virus because they so rarely get it.

The team analysed 18 studies looking into the link between the viral disease and children. Their findings, revealed on May 23, are yet to be published or peer-reviewed. 

The risk of catching Covid-19 in children and teenagers was 56 per cent lower compared to adults over 20.

Researchers did not have sufficient data to examine whether children under 12 differed to teenagers in susceptibility.

Under-18s also appear to account for just one in 10 family clusters of the viral disease, although this was based on just one study so the evidence is weak.

Lead author Professor Russell Viner told a press conference: ‘Susceptibility is a key part of the chain of infection, and this supports the view that children are likely to play a smaller role in transmitting the virus and proliferating the pandemic, although considerable uncertainty remains.’

Co-author Dr Rosalind Eggo, an infectious disease modeller at the London School of Hygiene and Tropical Medicine, said: ‘It [the study] suggests that children and young people are at lower risk of infection than adults and may therefore play a smaller role in the epidemic as a whole.

Evidence on how children spread the disease is ‘inconclusive’

The government’s SAGE experts suggested in May that children are at low danger from coronavirus but evidence on how they transmit the virus is ‘inconclusive’.

Although they admit there is no certainty, a raft of papers suggest that children are less likely to be infected and infectious than adults, and teachers do not seem at heightened risk.

The documents, prepared in the weeks up to May 1, float the idea of splitting classes in half and having children attend schools alternate weeks, saying that could slash the effect on the coronavirus ‘R’ number.

‘Evidence remains inconclusive on both the susceptibility and infectivity of children, but the balance of evidence suggests that both may be lower than in adults,’ one paper said. 

The government’s SAGE experts suggested in May that children are at low danger from coronavirus but evidence on how they transmit the virus is ‘inconclusive’. Pictured: Pupils at Greenacres Primary Academy in Oldham, northern England on June 18

What does the evidence say about severity of illness?

Children are unlikely to fall seriously ill and the risk of death is ‘very low’

A study found that the risks of coronavirus to children are very low, adding weight to previous research on the topic.

Researchers from Great Ormond Street Hospital in London looked at more than 582 children aged three and above who were diagnosed with Covid-19 across Europe during the height of the crisis in April.

The study found that, out of 363 children who went to hospital for treatment, fewer than one in 10 (8 per cent) needed intensive care.

The study – published in the journal Lancet Child & Adolescent Health on June 25 – also showed only 25 children needed mechanical ventilation (four per cent), but when they did need it, that support was typically required for a prolonged period, often for a week or more.

Four patients (0.68 per cent) died during the research — but academics cautioned the study only included patients who sought help and were tested for Covid-19.

This means milder cases would not have been included. For this reason they advise against extrapolating the numbers observed in their study to the wider population.

They say if milder cases were taken into consideration, the risk of being hospitalised or dying from Covid-19 for children would be drastically reduced.

Lead researcher Dr Marc Tebruegge, from the University College London Great Ormond Street Institute of Child Health in London, said the findings were ‘reassuring’.

Under-20s are half as likely to become sick with Covid-19 as over-70s

London School of Hygiene and Tropical Medicine academics analysed data from 32 locations in six different countries – China, Italy, Japan, Singapore, Canada and South Korea.

They found across all regions, under-20s are about half as susceptible to infection as people who are older, and only 21 per cent of infected 10 to 19-year-olds get symptoms.

In comparison, the rate among over-70s — considered to be the most vulnerable to the disease — was three times higher (69 per cent), according to the study that was published in the journal Nature Medicine on June 16.

Professor Mark Woolhouse, an epidemiologist at the University of Edinburgh, was not involved with the study but said: ‘[They] were not able to determine whether young people are also less infectious, though this could be the case if infectiousness is linked to the severity of symptoms.’

Reasons for children’s apparent resilience to the disease are still unclear, despite a wave of trials devoted to unraveling the truth on the contentious topic.

But top researchers say their immune system may be faster to react or their bodies are better able to cope with viral infections because they are younger.

Donald Trump insists children are immune to the coronavirus 

The US president Donald Trump has repeatedly insisted that children are immune from catching the coronavirus. Pictured,  Mr Trump speaks during a news conference at the White House in Washington yesterday

The US president Donald Trump has repeatedly insisted that children are immune from catching the coronavirus.

Asked on August 10 whether infections among young people gives him any pause, he said: ‘No. There may be a case, a tiny, a tiny fraction of death, tiny fraction, and they get better very quickly.’

Last week, social media platforms forced Mr Trump and his campaign to remove videos from their accounts in which the president claimed children are ‘virtually immune’ to the virus, which is false.

Asked if he still believes that, the president said: ‘For the most part, yeah, I think they do very well. They don’t catch it very easily … They don’t transport it or transfer it to other people, or certainly not very easily.’

However, the number of new Covid-19 cases among children in the US rose 40 per cent in the last two weeks of July, according to a report released just weeks before tens of millions of American students are scheduled to begin the new school year.

The new report by the American Academy of Pediatrics and the Children’s Hospital Association found that more than 338,000 children have tested positive for Covid-19 since the onset of the US epidemic, with 97,078 new cases reported in the July 16-30 period.

It did not give a reason for the recent spike. Testing for the novel coronavirus overall has risen in the US.

Source: Read Full Article